Uremic toxin indoxyl sulfate induces dysfunction of vascular smooth muscle cells via integrin-ß1/ERK signaling pathway.

Yu, Haibo; Zhou, Chunyu; Hu, Dayong; Li, Changbin; Wang, Qiang; Xue, Wen; Peng, Ai

Yu, Haibo; Zhou, Chunyu; Hu, Dayong; Li, Changbin; Wang, Qiang; Xue, Wen; Peng, Ai.

Afiliação

Yu H; Division of Nephrology, Center for Nephrology and Clinical Metabolomics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.
Zhou C; Division of Nephrology, Center for Nephrology and Clinical Metabolomics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.
Hu D; Division of Nephrology, Center for Nephrology and Clinical Metabolomics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.
Li C; Division of Nephrology, Center for Nephrology and Clinical Metabolomics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.
Wang Q; Department of Nephrology, Qilu Hospital of Shandong University (Qingdao), Qingdao, People's Republic of China.
Xue W; Division of Nephrology, Center for Nephrology and Clinical Metabolomics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China. xuewen1810668@126.com.
Peng A; Division of Nephrology, Center for Nephrology and Clinical Metabolomics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China. pengai@tongji.edu.cn.

Clin Exp Nephrol ; 26(7): 640-648, 2022 Jul.

Article em En | MEDLINE | ID: mdl-35333997

Assuntos

Doenças Cardiovasculares; Insuficiência Renal Crônica; Doenças Cardiovasculares/metabolismo; Células Endoteliais/metabolismo; Humanos; Indicã/toxicidade; Integrina beta1/genética; Sistema de Sinalização das MAP Quinases; Músculo Liso Vascular; Miócitos de Músculo Liso; Insuficiência Renal Crônica/metabolismo; Transdução de Sinais; Toxinas Urêmicas

Palavras-chave

Extracellular signal-regulated kinase; Indoxyl sulfate; Integrin-ß1; Protein-bound uremic toxins; Smooth muscle cells

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Insuficiência Renal Crônica Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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