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A Helquat-like Compound as a Potent Inhibitor of Flaviviral and Coronaviral Polymerases.
Konkolova, Eva; Krejcová, Katerina; Eyer, Ludek; Hodek, Jan; Zgarbová, Michala; Fortová, Andrea; Jirasek, Michael; Teply, Filip; Reyes-Gutierrez, Paul E; Ruzek, Daniel; Weber, Jan; Boura, Evzen.
Afiliação
  • Konkolova E; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i., Flemingovo nám. 2, 16610 Prague, Czech Republic.
  • Krejcová K; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i., Flemingovo nám. 2, 16610 Prague, Czech Republic.
  • Eyer L; Laboratory of Emerging Viral Diseases, Veterinary Research Institute, Hudcova 296/70, 62100 Brno, Czech Republic.
  • Hodek J; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i., Flemingovo nám. 2, 16610 Prague, Czech Republic.
  • Zgarbová M; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i., Flemingovo nám. 2, 16610 Prague, Czech Republic.
  • Fortová A; Laboratory of Emerging Viral Diseases, Veterinary Research Institute, Hudcova 296/70, 62100 Brno, Czech Republic.
  • Jirasek M; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i., Flemingovo nám. 2, 16610 Prague, Czech Republic.
  • Teply F; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i., Flemingovo nám. 2, 16610 Prague, Czech Republic.
  • Reyes-Gutierrez PE; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i., Flemingovo nám. 2, 16610 Prague, Czech Republic.
  • Ruzek D; Laboratory of Emerging Viral Diseases, Veterinary Research Institute, Hudcova 296/70, 62100 Brno, Czech Republic.
  • Weber J; Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, Branisovská 1160/31, 37005 Ceske Budejovice, Czech Republic.
  • Boura E; Department of Experimental Biology, Faculty of Science, Masaryk University, 62500 Brno, Czech Republic.
Molecules ; 27(6)2022 Mar 15.
Article em En | MEDLINE | ID: mdl-35335258
Positive-sense single-stranded RNA (+RNA) viruses have proven to be important pathogens that are able to threaten and deeply damage modern societies, as illustrated by the ongoing COVID-19 pandemic. Therefore, compounds active against most or many +RNA viruses are urgently needed. Here, we present PR673, a helquat-like compound that is able to inhibit the replication of SARS-CoV-2 and tick-borne encephalitis virus in cell culture. Using in vitro polymerase assays, we demonstrate that PR673 inhibits RNA synthesis by viral RNA-dependent RNA polymerases (RdRps). Our results illustrate that the development of broad-spectrum non-nucleoside inhibitors of RdRps is feasible.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vírus da Encefalite Transmitidos por Carrapatos / COVID-19 Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vírus da Encefalite Transmitidos por Carrapatos / COVID-19 Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article