Production of Atosiban's Key Intermediate Pentapeptide: Synthetic Approaches to the Development of a Peptide Synthesis with Less Racemization and Simplifier Purification Process.
Molecules
; 27(6)2022 Mar 16.
Article
em En
| MEDLINE
| ID: mdl-35335281
ABSTRACT
The key intermediate NH2-Ile-Thr(Bzl)-Asn-Cys(Bzl)-Pro-COOH of Atosiban was prepared from N-Boc-S-Bzl-cysteine by the stepwise lengthening of the chain according to the repetitive N,O-bis(trimethylsilyl)acetamide/N-hydroxysuccinimide ester (BSA/NHS) strategy. This synthetic route required no chromatography purification and can be readily performed, yielding a highly pure pentapeptide compound.
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MEDLINE
Assunto principal:
Vasotocina
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Cisteína
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article