Effect of Inter-Domain Linker Composition on Biodistribution of ABD-Fused Affibody-Drug Conjugates Targeting HER2.

Xu, Tianqi; Zhang, Jie; Oroujeni, Maryam; Tretyakova, Maria S; Bodenko, Vitalina; Belousov, Mikhail V; Orlova, Anna; Tolmachev, Vladimir; Vorobyeva, Anzhelika; Gräslund, Torbjörn.

Afiliação

Xu T; Department of Immunology, Genetics and Pathology, Uppsala University, 751 85 Uppsala, Sweden.
Zhang J; Department of Protein Science, KTH Royal Institute of Technology, Roslagstullsbacken 21, 114 17 Stockholm, Sweden.
Oroujeni M; Department of Immunology, Genetics and Pathology, Uppsala University, 751 85 Uppsala, Sweden.
Tretyakova MS; Department of Science and Development, Affibody AB, 171 65 Solna, Sweden.
Bodenko V; Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, 634050 Tomsk, Russia.
Belousov MV; Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 634009 Tomsk, Russia.
Orlova A; Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, 634050 Tomsk, Russia.
Tolmachev V; Department of Pharmaceutical Analysis, Siberian State Medical University, Ministry of Health of the Russian Federation, 634050 Tomsk, Russia.
Vorobyeva A; Research School of Chemistry and Applied Biomedical Sciences, National Research Tomsk Polytechnic University, 634050 Tomsk, Russia.
Gräslund T; Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, 634050 Tomsk, Russia.