The PIK3CA H1047R Mutation Confers Resistance to BRAF and MEK Inhibitors in A375 Melanoma Cells through the Cross-Activation of MAPK and PI3K-Akt Pathways.

Candido, Saverio; Salemi, Rossella; Piccinin, Sara; Falzone, Luca; Libra, Massimo

Candido, Saverio; Salemi, Rossella; Piccinin, Sara; Falzone, Luca; Libra, Massimo.

Afiliação

Candido S; Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy.
Salemi R; Research Centre for Prevention, Diagnosis, and Treatment of Cancer, University of Catania, 95123 Catania, Italy.
Piccinin S; Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy.
Falzone L; Unit of Oncogenetics and Functional Oncogenomics, Centro di Riferimento Oncologico di Aviano (CRO Aviano) IRCCS, National Cancer Institute, 33081 Aviano, Italy.
Libra M; Epidemiology and Biostatistics Unit, National Cancer Institute-IRCCS 'Fondazione G. Pascale', 80131 Naples, Italy.

Pharmaceutics ; 14(3)2022 Mar 08.

Article em En | MEDLINE | ID: mdl-35335966