[Contamination status and the health risk evaluation of dietary exposure of quinolone and tetracycline antibiotics in animal derived foods in Ningbo City from 2018 to 2020].

ABSTRACT

OBJECTIVE: To investigate the dietary exposure of Ningbo residents to quinolones and tetracyclines antibiotics in animal derived foods, so as to estimate the health risk caused by the exposure. METHODS: Animal derived foods in Ningbo markets from 2018 to 2020 were collected and analyzed by ultra-fast liquid chromatography-tandem mass spectrometry. Based on the result of the measurements, median(M), P97.5, average and the maximum values of the data were obtained. Coupling the food intake data of residents in Zhejiang Province, an international point estimate model was applied to evaluate the health risk caused by the dietary exposure. RESULTS: Enrofloxacin, ciprofloxacin, ofloxacin, doxycycline, oxytetracycline were detected in freshwater fishes, cultured pseudosciaena crocea, freshwater shrimps, chicken, eggs and pork. The detection rates of enrofloxacin, ciprofloxacin, ofloxacin, doxycycline, oxytetracycline were 21.2%(77/363), 11.6%(42/363), 2.8%(10/363), 1.4%(5/363), 0.6%(2/363), respectively. The dietary exposure of adults and children from animal derived foods were in the range of 0.8-909.0 and 0.6-518.9 ng/(kg·d), respectively. The hazard quotient(HQ) values were in the range of 0.000030-0.17. CONCLUSION: Quinolone and tetracycline antibiotics such as enrofloxacin and oxytetracycline have no dietary health risk to the population.