Autoregulation of switching behavior by cellular compartment size.
Proc Natl Acad Sci U S A
; 119(14): e2116054119, 2022 04 05.
Article
em En
| MEDLINE
| ID: mdl-35349334
ABSTRACT
SignificanceBiochemical reactions often occur in small volumes within a cell, restricting the number of molecules to the hundreds or even tens. At this scale, reactions are discrete and stochastic, making reliable signaling difficult. This paper shows that the transition between discrete, stochastic reactions and macroscopic reactions can be exploited to make a self-regulating switch. This constitutes a previously unidentified kind of reaction network that may be present in small structures, such as synapses.
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Base de dados:
MEDLINE
Assunto principal:
Sinapses
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Proteína Quinase Tipo 2 Dependente de Cálcio-Calmodulina
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article