Transient changes to metabolic homeostasis initiate mitochondrial adaptation to endurance exercise.
Semin Cell Dev Biol
; 143: 3-16, 2023 07 15.
Article
em En
| MEDLINE
| ID: mdl-35351374
ABSTRACT
Endurance exercise is well established to increase mitochondrial content and function in skeletal muscle, a process termed mitochondrial biogenesis. Current understanding is that exercise initiates skeletal muscle mitochondrial remodeling via modulation of cellular nutrient, energetic and contractile stress pathways. These subtle changes in the cellular milieu are sensed by numerous transduction pathways that serve to initiate and coordinate an increase in mitochondrial gene transcription and translation. The result of these acute signaling events is the promotion of growth and assembly of mitochondria, coupled to a greater capacity for aerobic ATP provision in skeletal muscle. The aim of this review is to highlight the acute metabolic events induced by endurance exercise and the subsequent molecular pathways that sense this transient change in cellular homeostasis to drive mitochondrial adaptation and remodeling.
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Base de dados:
MEDLINE
Assunto principal:
Exercício Físico
/
Mitocôndrias
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article