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Highly efficient prime editing by introducing same-sense mutations in pegRNA or stabilizing its structure.
Li, Xiaosa; Zhou, Lina; Gao, Bao-Qing; Li, Guangye; Wang, Xiao; Wang, Ying; Wei, Jia; Han, Wenyan; Wang, Zixian; Li, Jifang; Gao, Runze; Zhu, Junjie; Xu, Wenchao; Wu, Jing; Yang, Bei; Sun, Xiaodong; Yang, Li; Chen, Jia.
Afiliação
  • Li X; Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 200080, Shanghai, China. xiaosa.li@shgh.cn.
  • Zhou L; Shanghai Key Laboratory of Fundus Diseases, 200080, Shanghai, China. xiaosa.li@shgh.cn.
  • Gao BQ; Gene Editing Center, School of Life Science and Technology, ShanghaiTech University, 201210, Shanghai, China. xiaosa.li@shgh.cn.
  • Li G; Gene Editing Center, School of Life Science and Technology, ShanghaiTech University, 201210, Shanghai, China.
  • Wang X; Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, 200031, Shanghai, China.
  • Wang Y; University of Chinese Academy of Sciences, 100049, Beijing, China.
  • Wei J; Shanghai Clinical Research and Trial Center, 201210, Shanghai, China.
  • Han W; CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 200031, Shanghai, China.
  • Wang Z; Gene Editing Center, School of Life Science and Technology, ShanghaiTech University, 201210, Shanghai, China.
  • Li J; Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, 200031, Shanghai, China.
  • Gao R; University of Chinese Academy of Sciences, 100049, Beijing, China.
  • Zhu J; Gene Editing Center, School of Life Science and Technology, ShanghaiTech University, 201210, Shanghai, China.
  • Xu W; Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, 200031, Shanghai, China.
  • Wu J; University of Chinese Academy of Sciences, 100049, Beijing, China.
  • Yang B; CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 200031, Shanghai, China.
  • Sun X; CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 200031, Shanghai, China.
  • Yang L; Gene Editing Center, School of Life Science and Technology, ShanghaiTech University, 201210, Shanghai, China.
  • Chen J; Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, 200031, Shanghai, China.
Nat Commun ; 13(1): 1669, 2022 03 29.
Article em En | MEDLINE | ID: mdl-35351879
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sistemas CRISPR-Cas / Edição de Genes Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sistemas CRISPR-Cas / Edição de Genes Idioma: En Ano de publicação: 2022 Tipo de documento: Article