Tail-approach based design and synthesis of Arylthiazolylhydrazono-1,2,3-triazoles incorporating sulfanilamide and metanilamide as human carbonic anhydrase I, II, IV and IX inhibitors.

Kumar, Amit; Siwach, Kiran; Rom, Tanmay; Kumar, Rajiv; Angeli, Andrea; Kumar Paul, Avijit; Supuran, Claudiu T; Sharma, Pawan K

Kumar, Amit; Siwach, Kiran; Rom, Tanmay; Kumar, Rajiv; Angeli, Andrea; Kumar Paul, Avijit; Supuran, Claudiu T; Sharma, Pawan K.

Afiliação

Kumar A; Department of Chemistry, Kurukshetra University, Kurukshetra 136119, Haryana, India.
Siwach K; Department of Chemistry, Kurukshetra University, Kurukshetra 136119, Haryana, India.
Rom T; Department of Chemistry, National Institute of Technology Kurukshetra, Kurukshetra 136119, Haryana, India.
Kumar R; Ch. Mani Ram Godara Government College for Women, Bhodia Khera, Fatehabad 125050, Haryana, India.
Angeli A; Department of Neurosciences, Psychology, Drug Research and Child Health, Pharmaceutical and Nutraceutical Section, University of Florence, Florence, Italy.
Kumar Paul A; Department of Chemistry, National Institute of Technology Kurukshetra, Kurukshetra 136119, Haryana, India.
Supuran CT; Department of Neurosciences, Psychology, Drug Research and Child Health, Pharmaceutical and Nutraceutical Section, University of Florence, Florence, Italy. Electronic address: claudiu.supuran@unifi.it.
Sharma PK; Department of Chemistry, Kurukshetra University, Kurukshetra 136119, Haryana, India. Electronic address: pksharma@kuk.ac.in.

Bioorg Chem ; 123: 105764, 2022 06.

Article em En | MEDLINE | ID: mdl-35366582

Assuntos

Anidrase Carbônica I; Inibidores da Anidrase Carbônica; Antígenos de Neoplasias; Anidrase Carbônica I/metabolismo; Anidrase Carbônica II; Anidrase Carbônica IV; Anidrase Carbônica IX; Inibidores da Anidrase Carbônica/química; Humanos; Estrutura Molecular; Relação Estrutura-Atividade; Sulfanilamida; Sulfonamidas/química; Triazóis/química; Triazóis/farmacologia

Palavras-chave

1,2,3-triazole; Benzenesulfonamide; Carbonic anhydrase inhibitors; SLC-0111; Tail-approach; hCA isoforms

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores da Anidrase Carbônica / Anidrase Carbônica I Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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