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Pembrolizumab versus placebo as adjuvant therapy in completely resected stage IIB or IIC melanoma (KEYNOTE-716): a randomised, double-blind, phase 3 trial.
Luke, Jason J; Rutkowski, Piotr; Queirolo, Paola; Del Vecchio, Michele; Mackiewicz, Jacek; Chiarion-Sileni, Vanna; de la Cruz Merino, Luis; Khattak, Muhammad A; Schadendorf, Dirk; Long, Georgina V; Ascierto, Paolo A; Mandala, Mario; De Galitiis, Federica; Haydon, Andrew; Dummer, Reinhard; Grob, Jean-Jacques; Robert, Caroline; Carlino, Matteo S; Mohr, Peter; Poklepovic, Andrew; Sondak, Vernon K; Scolyer, Richard A; Kirkwood, John M; Chen, Ke; Diede, Scott J; Ahsan, Sama; Ibrahim, Nageatte; Eggermont, Alexander M M.
Afiliação
  • Luke JJ; UPMC Hillman Cancer Center, Pittsburgh, PA, USA. Electronic address: lukejj@upmc.edu.
  • Rutkowski P; Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.
  • Queirolo P; Istituto Europeo di Oncologia - IRCCS, Milano; Ospedale San Martino IRCCS, Genova, Italy.
  • Del Vecchio M; Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.
  • Mackiewicz J; Poznan University of Medical Sciences, Poznan, Poland; Greater Poland Cancer Center, Poznan, Poland.
  • Chiarion-Sileni V; Istituto Oncologico Veneto, IOV-IRCCS, Padova, Italy.
  • de la Cruz Merino L; Clinical Oncology Department, Hospital Universitario Virgen Macarena, Sevilla, Spain; Medicine Department, Universidad de Sevilla, Sevilla, Spain.
  • Khattak MA; Fiona Stanley Hospital & Edith Cowan University, Perth, WA, Australia.
  • Schadendorf D; University Hospital Essen and German Cancer Consortium Partner Site, Essen, Germany.
  • Long GV; Melanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia; Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia; Charles Perkins Center, The University of Sydney, Sydney, NSW, Australia; Royal North Shore and Mater Hospitals, Sydney, NSW, Australia.
  • Ascierto PA; Istituto Nazionale Tumori IRCCS Fondazione Pascale, Naples, Italy.
  • Mandala M; University of Perugia, Perugia, Italy; Ospedale Papa Giovanni XXIII, Bergamo, Italy.
  • De Galitiis F; Dermopathic Institute of the Immaculate IDI-IRCCS, Rome, Italy.
  • Haydon A; Alfred Hospital, Monash University, Melbourne, VIC, Australia.
  • Dummer R; University Hospital Zürich, University of Zurich, Skin Cancer Center, Zurich, Switzerland.
  • Grob JJ; AP-HM Hospital, Aix-Marseille University, Marseille, France.
  • Robert C; Institut Gustave Roussy, Villejuif, France; Paris-Saclay University, Villejuif, France.
  • Carlino MS; Melanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia; Westmead and Blacktown Hospitals, Sydney, NSW, Australia.
  • Mohr P; Elbe Kliniken Buxtehude, Buxtehude, Germany.
  • Poklepovic A; VCU Massey Cancer Center, Richmond, VA, USA.
  • Sondak VK; H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
  • Scolyer RA; Melanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia; Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia; Charles Perkins Center, The University of Sydney, Sydney, NSW, Australia; Royal Prince Alfred Hospital Sydney, NSW, Australia; NSW Health
  • Kirkwood JM; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
  • Chen K; Merck & Co, Inc., Kenilworth, NJ, USA.
  • Diede SJ; Merck & Co, Inc., Kenilworth, NJ, USA.
  • Ahsan S; Merck & Co, Inc., Kenilworth, NJ, USA.
  • Ibrahim N; Merck & Co, Inc., Kenilworth, NJ, USA.
  • Eggermont AMM; University Medical Center Utrecht, Utrecht, Netherlands; Princess Máxima Center, Utrecht, Netherlands; Comprehensive Cancer Center Munich, Munich, Germany.
Lancet ; 399(10336): 1718-1729, 2022 04 30.
Article em En | MEDLINE | ID: mdl-35367007
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Testiculares / COVID-19 / Melanoma Tipo de estudo: Clinical_trials Limite: Child / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Testiculares / COVID-19 / Melanoma Tipo de estudo: Clinical_trials Limite: Child / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2022 Tipo de documento: Article