Molecular connections between circadian clock and health/ageing.
J Biochem
; 171(5): 473-476, 2022 May 11.
Article
em En
| MEDLINE
| ID: mdl-35383844
ABSTRACT
For decades, considerable efforts have been expended for solving the molecular mechanisms of disease progression. An important clue to tackle this question is the circadian clock. Recent findings have uncovered previously unknown molecular connections between circadian clock and disease incidence, consequently causing the ageing process. Furthermore, 'chronotherapy' is emerging as a new concept of optimizing the time of the day for drug administration according to target gene expressions in order to maximize therapeutic efficacy and minimize the side effects. This concept will help cure patients and prevent them from suffering evitable pain and side effects. This JB special issue 'Molecular connections between circadian clock and health/aging' discusses how the circadian clocks link to health and ageing from molecular to organismal levels.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Relógios Circadianos
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article