Oncogenic RAS sensitizes cells to drug-induced replication stress via transcriptional silencing of P53.

Segeren, Hendrika A; van Liere, Elsbeth A; Riemers, Frank M; de Bruin, Alain; Westendorp, Bart

Segeren, Hendrika A; van Liere, Elsbeth A; Riemers, Frank M; de Bruin, Alain; Westendorp, Bart.

Afiliação

Segeren HA; Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
van Liere EA; Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
Riemers FM; Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
de Bruin A; Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
Westendorp B; Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.

Oncogene ; 41(19): 2719-2733, 2022 05.

Article em En | MEDLINE | ID: mdl-35393546

Assuntos

Genes ras; Proteína Supressora de Tumor p53; Proteínas Mutadas de Ataxia Telangiectasia/genética; Quinase 1 do Ponto de Checagem/genética; Dano ao DNA; Replicação do DNA/genética; Humanos; Inibidores de Proteínas Quinases/farmacologia; Transdução de Sinais; Proteína Supressora de Tumor p53/genética

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteína Supressora de Tumor p53 / Genes ras Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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