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Clinical Significance of Serum Zinc Levels on the Development of Sarcopenia in Cirrhotic Patients.
Murata, Koji; Namisaki, Tadashi; Fujimoto, Yuki; Takeda, Soichi; Enomoto, Masahide; Takaya, Hiroaki; Tsuji, Yuki; Shibamoto, Akihiko; Suzuki, Junya; Kubo, Takahiro; Iwai, Satoshi; Tomooka, Fumimasa; Tanaka, Misako; Kaneko, Miki; Asada, Shohei; Koizumi, Aritoshi; Yorioka, Nobuyuki; Matsuda, Takuya; Ozutsumi, Takahiro; Ishida, Koji; Ogawa, Hiroyuki; Takagi, Hirotetsu; Fujinaga, Yukihisa; Furukawa, Masanori; Sawada, Yasuhiko; Nishimura, Norihisa; Kitagawa, Koh; Sato, Shinya; Kaji, Kosuke; Inoue, Takashi; Asada, Kiyoshi; Kawaratani, Hideto; Moriya, Kei; Akahane, Takemi; Mitoro, Akira; Yoshiji, Hitoshi.
Afiliação
  • Murata K; Department of Gastroenterology of Nara Medical University, Kashihara, Japan.
  • Namisaki T; Department of Gastroenterology of Nara Medical University, Kashihara, Japan.
  • Fujimoto Y; Department of Gastroenterology of Nara Medical University, Kashihara, Japan.
  • Takeda S; Department of Gastroenterology of Nara Medical University, Kashihara, Japan.
  • Enomoto M; Department of Gastroenterology of Nara Medical University, Kashihara, Japan.
  • Takaya H; Department of Gastroenterology of Nara Medical University, Kashihara, Japan.
  • Tsuji Y; Department of Gastroenterology of Nara Medical University, Kashihara, Japan.
  • Shibamoto A; Department of Gastroenterology of Nara Medical University, Kashihara, Japan.
  • Suzuki J; Department of Gastroenterology of Nara Medical University, Kashihara, Japan.
  • Kubo T; Department of Gastroenterology of Nara Medical University, Kashihara, Japan.
  • Iwai S; Department of Gastroenterology of Nara Medical University, Kashihara, Japan.
  • Tomooka F; Department of Gastroenterology of Nara Medical University, Kashihara, Japan.
  • Tanaka M; Department of Gastroenterology of Nara Medical University, Kashihara, Japan.
  • Kaneko M; Department of Gastroenterology of Nara Medical University, Kashihara, Japan.
  • Asada S; Department of Gastroenterology of Nara Medical University, Kashihara, Japan.
  • Koizumi A; Department of Gastroenterology of Nara Medical University, Kashihara, Japan.
  • Yorioka N; Department of Gastroenterology of Nara Medical University, Kashihara, Japan.
  • Matsuda T; Department of Gastroenterology of Nara Medical University, Kashihara, Japan.
  • Ozutsumi T; Department of Gastroenterology of Nara Medical University, Kashihara, Japan.
  • Ishida K; Department of Gastroenterology of Nara Medical University, Kashihara, Japan.
  • Ogawa H; Department of Gastroenterology of Nara Medical University, Kashihara, Japan.
  • Takagi H; Department of Gastroenterology of Nara Medical University, Kashihara, Japan.
  • Fujinaga Y; Department of Gastroenterology of Nara Medical University, Kashihara, Japan.
  • Furukawa M; Department of Gastroenterology of Nara Medical University, Kashihara, Japan.
  • Sawada Y; Department of Gastroenterology of Nara Medical University, Kashihara, Japan.
  • Nishimura N; Department of Gastroenterology of Nara Medical University, Kashihara, Japan.
  • Kitagawa K; Department of Gastroenterology of Nara Medical University, Kashihara, Japan.
  • Sato S; Department of Gastroenterology of Nara Medical University, Kashihara, Japan.
  • Kaji K; Department of Gastroenterology of Nara Medical University, Kashihara, Japan.
  • Inoue T; Institute for Clinical and Translational Science, Nara Medical University Hospital, Kashihara, Japan.
  • Asada K; Institute for Clinical and Translational Science, Nara Medical University Hospital, Kashihara, Japan.
  • Kawaratani H; Department of Gastroenterology of Nara Medical University, Kashihara, Japan.
  • Moriya K; Department of Gastroenterology of Nara Medical University, Kashihara, Japan.
  • Akahane T; Department of Gastroenterology of Nara Medical University, Kashihara, Japan.
  • Mitoro A; Department of Gastroenterology of Nara Medical University, Kashihara, Japan.
  • Yoshiji H; Department of Gastroenterology of Nara Medical University, Kashihara, Japan.
Cancer Diagn Progn ; 2(2): 184-193, 2022.
Article em En | MEDLINE | ID: mdl-35399181
ABSTRACT
Background/

Aim:

Sarcopenia increases the mortality in patients with cirrhosis. Approximately 60% of zinc is accumulated in skeletal muscle. We aimed to determine the role of subclinical zinc deficiency on sarcopenia development in patients with cirrhosis. Patients and

Methods:

We enrolled 151 patients with cirrhosis and divided them into the group with normal serum zinc levels (Group N 80-130 µg/dl; n=38) and group with subclinical zinc deficiency (Group D <80 µg/dl; n=113). The risk factors for sarcopenia were then investigated.

Results:

Group D had more sarcopenia cases than Group N (31.0% vs. 13.2%). In group D, HGS exhibited a weakly positive but significant correlation with serum zinc levels (R=0.287, p=0.00212), serum zinc levels negatively correlated with both ammonia and myostatin levels (R=-0.254, p=0.0078; R=-0.33, p<0.01), and low zinc levels were independently associated with sarcopenia development.

Conclusion:

Patients with cirrhosis showing subclinical zinc deficiency have a significantly higher risk of developing sarcopenia.
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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Ano de publicação: 2022 Tipo de documento: Article