Empagliflozin alleviates myocardial I/R injury and cardiomyocyte apoptosis via inhibiting ER stress-induced autophagy and the PERK/ATF4/Beclin1 pathway.

Wang, Cuan-Cuan; Li, Ying; Qian, Xiao-Qian; Zhao, Hui; Wang, Dong; Zuo, Guo-Xing; Wang, Kuan

Wang, Cuan-Cuan; Li, Ying; Qian, Xiao-Qian; Zhao, Hui; Wang, Dong; Zuo, Guo-Xing; Wang, Kuan.

Afiliação

Wang CC; Department of Cardiology, Tianjin Fifth Central Hospital, Tianjin, China.
Li Y; Department of Cardiology, Tianjin Fifth Central Hospital, Tianjin, China.
Qian XQ; Department of Cardiology, Tianjin Fifth Central Hospital, Tianjin, China.
Zhao H; Department of Cardiology, Tianjin Fifth Central Hospital, Tianjin, China.
Wang D; Department of Cardiology, Tianjin Fifth Central Hospital, Tianjin, China.
Zuo GX; Department of Cardiology, Tianjin Fifth Central Hospital, Tianjin, China.
Wang K; Department of Cardiology, Tianjin Fifth Central Hospital, Tianjin, China.

J Drug Target ; 30(8): 858-872, 2022 09.

Article em En | MEDLINE | ID: mdl-35400245

Assuntos

Traumatismo por Reperfusão Miocárdica; Animais; Apoptose; Autofagia; Proteína Beclina-1; Compostos Benzidrílicos; Estresse do Retículo Endoplasmático; Glucosídeos; Peróxido de Hidrogênio/metabolismo; Camundongos; Traumatismo por Reperfusão Miocárdica/tratamento farmacológico; Miócitos Cardíacos

Palavras-chave

ER stress; Empagliflozin; I/R injury; PERK/ATF4/Beclin1 signalling; autophagy; cardiomyocyte apoptosis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Traumatismo por Reperfusão Miocárdica Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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