Bioactive Terphenyls Isolated from the Antarctic Lichen Stereocaulon alpinum.
Molecules
; 27(7)2022 Apr 06.
Article
em En
| MEDLINE
| ID: mdl-35408757
ABSTRACT
Three p-terphenyls (2-4)-2-hydroxy-3,5-dimethoxy-p-terphenyl (2), 2-hydroxy-3,6-dimethoxy-p-terphenyl (3), and 2,3,5,6-tetramethoxy-p-terphenyl (4)-were isolated for the first time as natural products along with seven known compounds (1, 5-10) from the Antarctic lichen Stereocaulon alpinum. Structures of the new compounds were elucidated by comprehensive analyses of 1D and 2D NMR and HREIMS experiments. Compound 3 exhibited cytotoxicity against HCT116 cells with the IC50 value of 3.76 ± 0.03 µM and also inhibited NO production in LPS-induced RAW264.7 macrophages with the IC50 value of 22.82 ± 0.015 µM.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Ascomicetos
/
Compostos de Terfenil
/
Líquens
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article