Your browser doesn't support javascript.
loading
Structural diversity using amino acid "Customizable Units": conversion of hydroxyproline (Hyp) into nitrogen heterocycles.
Hernández, Dácil; Porras, Marina; Boto, Alicia.
Afiliação
  • Hernández D; Instituto de Productos Naturales y Agrobiología del CSIC, Avda. Astrofísico Francisco Sánchez, 3, 38206, La Laguna, Tenerife, Spain. dacil@ipna.csic.es.
  • Porras M; Instituto de Productos Naturales y Agrobiología del CSIC, Avda. Astrofísico Francisco Sánchez, 3, 38206, La Laguna, Tenerife, Spain.
  • Boto A; Instituto de Productos Naturales y Agrobiología del CSIC, Avda. Astrofísico Francisco Sánchez, 3, 38206, La Laguna, Tenerife, Spain. alicia@ipna.csic.es.
Amino Acids ; 54(6): 955-966, 2022 Jun.
Article em En | MEDLINE | ID: mdl-35414005
ABSTRACT
The ability of amino acid "customizable units" to generate structural diversity is illustrated by the conversion of 4-hydroxyproline (Hyp) units into a variety of nitrogen heterocycles. After a first common step, where the unit underwent a one-pot decarboxylation-alkylation reaction to afford 2-alkylpyrrolidines with high stereoselectivity, a divergent step was carried out. Thus, the deprotected 4-hydroxy group was used either to initiate a radical scission that afforded aliphatic ß-amino aldehydes, or to carry out an elimination reaction, to give 2-alkyl-2,5-dihydro-1H-pyrroles. In the first case, the amines underwent a tandem reductive amination-cyclization to afford ß-amino-δ-lactams, an efficient rigidifying unit in peptides. Different lactam N-substituents, such as alkylamines, peptides, and alkenyl chains suitable for olefin metathesis were introduced this way. In the second case, the pyrrole derivatives were efficiently converted into alkaloid and iminosugar derivatives in good global yields and with excellent stereoselectivity.
Assuntos
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aminoácidos / Nitrogênio Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aminoácidos / Nitrogênio Idioma: En Ano de publicação: 2022 Tipo de documento: Article