Cytotoxic and antileishmanial triterpenes of Tabebuia aurea (Silva Manso) leaves.
Nat Prod Res
; 36(23): 6181-6185, 2022 Dec.
Article
em En
| MEDLINE
| ID: mdl-35416746
ABSTRACT
The bioactivity-guided fractionation of the total ethanolic extract of the leaves of Tabebuia aurea revealed the cytotoxic and antileishmanial potency of the ethyl acetate fraction, in which its phytochemical investigation resulted in the isolation of five triterpenes; identified as oleanolic acid (1), ursolic acid (2), pomolic acid (3), tormentic acid (4), 3ß,6ß,19α-trihydroxy-urs-12-en-28-oic acid (5) in addition to one triterpenoid glucoside, spathodic acid 28-O-ß-D-glucopyranoside (6). Whereas compound 1 showed cytotoxic activity against three different cell lines; A549, MCF-7 and HepG2 with IC50 values of 31.7 ± 1.2, 27.4 ± 1.8 and 28.8 ± 1.1 µg/mL, respectively (etoposide as a positive control 28.1 ± 4.2, 22.5 ± 4.5, and 20.4 ± 0.8 µg/mL, respectively), while compounds 1 and 2 showed antileishmanial activity with IC50 values of 10.2 ± 0.9 µg/mL and 5.1 ± 0.4 µg/mL, respectively (miltefosine 7.7 ± 2.1 µg/mL).
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Base de dados:
MEDLINE
Assunto principal:
Triterpenos
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Bignoniaceae
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Tabebuia
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Antineoplásicos
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Antiprotozoários
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article