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5-Fluorouracil Neurotoxicity in the Absence of Dihydropyrimidine Dehydrogenase Deficiency Case Report.
Jules, Rebecca; Thaper, Arushi; Foster, Ryan; Ameli, Pouya; Robinson, Christopher; Pizzi, Michael; Babi, Marc-Alain; Maciel, Carolina B; Busl, Katharina M; Reddy, Raju; Roth, William.
Afiliação
  • Jules R; University of Florida College of Medicine, Gainesville, FL, USA.
  • Thaper A; Department of Internal Medicine, University of Florida College of Medicine, Gainesville, FL, USA.
  • Foster R; Department of Internal Medicine, University of Florida College of Medicine, Gainesville, FL, USA.
  • Ameli P; Department of Neurology, Neurocritical Care Division, University of Florida College of Medicine, Gainesville, FL, USA.
  • Robinson C; Department of Neurology, Neurocritical Care Division, University of Florida College of Medicine, Gainesville, FL, USA.
  • Pizzi M; Department of Neurology, Neurocritical Care Division, University of Florida College of Medicine, Gainesville, FL, USA.
  • Babi MA; Department of Neurology, Neurocritical Care Division, University of Florida College of Medicine, Gainesville, FL, USA.
  • Maciel CB; Department of Neurology, Neurocritical Care Division, University of Florida College of Medicine, Gainesville, FL, USA.
  • Busl KM; Department of Neurology, Neurocritical Care Division, University of Florida College of Medicine, Gainesville, FL, USA.
  • Reddy R; Department of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University of Florida College of Medicine, Gainesville, FL, USA.
  • Roth W; Department of Neurology, Neurocritical Care Division, University of Florida College of Medicine, Gainesville, FL, USA.
Neurohospitalist ; 12(2): 366-370, 2022 Apr.
Article em En | MEDLINE | ID: mdl-35419161
ABSTRACT
5 fluorouracil (5-FU)-related neurotoxicity is a rare and severe complication of 5-FU administration. Dihydropyrimidine dehydrogenase (DPD) deficiency is associated with an increased risk of serious adverse reactions due to its role in 5-FU metabolism. We report a case of acute reversible neurotoxicity with global areas of diffusion restriction in a patient with colorectal adenocarcinoma being treated with leucovorin calcium, 5-fluorouracil, and oxaliplatin (FOLFOX) without DPD deficiency following uridine triacetate administration.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article