SPF45/RBM17-dependent splicing and multidrug resistance to cancer chemotherapy.

Fukumura, Kazuhiro; Venables, Julian P; Mayeda, Akila

Fukumura, Kazuhiro; Venables, Julian P; Mayeda, Akila.

Afiliação

Fukumura K; Division of Gene Expression Mechanism, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi, Japan.
Venables JP; Science Sense, 2 Rue St Vincent, Salèlles du Bosc, 34700 Le Bosc, France.
Mayeda A; Division of Gene Expression Mechanism, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi, Japan.

Mol Cell Oncol ; 8(6): 1996318, 2021.

Article em En | MEDLINE | ID: mdl-35419480

ABSTRACT

ABSTRACT

The early splicing complex A occupies at least eighty nucleotides of intron, in which U2AF covers the polypyrimidine tract. SPF45 (RBM17) functionally substitutes for U2AF on a subset of short introns. Since SPF45 expression confers resistance to various anticancer drugs, SPF45-dependent splicing may play a critical role in multidrug resistance.

Palavras-chave

Pre-mRNA splicing; SPF45 (RBM17); U2AF heterodimer; anticancer drug resistance; short intron

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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