Your browser doesn't support javascript.
loading
Two New Austocystin Analogs from the Marine-Derived Fungus Aspergillus sp. WHUF05236.
Lv, Huawei; Zhang, Jinkun; Xue, Yaxin; Li, Songwei; Sun, Xiaoyu; Jia, Jia; Bi, Hongkai; Wang, Shoubao; Su, Haibo; Zhu, Mengdi; Wang, Hong; Hong, Kui; Li, Xingnuo.
Afiliação
  • Lv H; College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Key Laboratory of Marine Fishery Resources Exploitment & Utilization of Zhejiang Province, Zhejiang University of Technology, 310014, Hangzhou, P. R. China.
  • Zhang J; College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Key Laboratory of Marine Fishery Resources Exploitment & Utilization of Zhejiang Province, Zhejiang University of Technology, 310014, Hangzhou, P. R. China.
  • Xue Y; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, 430071, Wuhan, P. R. China.
  • Li S; College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Key Laboratory of Marine Fishery Resources Exploitment & Utilization of Zhejiang Province, Zhejiang University of Technology, 310014, Hangzhou, P. R. China.
  • Sun X; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, 430071, Wuhan, P. R. China.
  • Jia J; Department of Pathogen Biology & Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University, 211166, Nanjing, P. R. China.
  • Bi H; Department of Pathogen Biology & Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University, 211166, Nanjing, P. R. China.
  • Wang S; Beijing Key Laboratory of Drug Target Research and New Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences, 100050, Beijing, P. R. China.
  • Su H; College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Key Laboratory of Marine Fishery Resources Exploitment & Utilization of Zhejiang Province, Zhejiang University of Technology, 310014, Hangzhou, P. R. China.
  • Zhu M; Research Center of Analysis and Measurement, Zhejiang University of Technology, 310014, Hangzhou, P. R. China.
  • Wang H; College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Key Laboratory of Marine Fishery Resources Exploitment & Utilization of Zhejiang Province, Zhejiang University of Technology, 310014, Hangzhou, P. R. China.
  • Hong K; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, 430071, Wuhan, P. R. China.
  • Li X; College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Key Laboratory of Marine Fishery Resources Exploitment & Utilization of Zhejiang Province, Zhejiang University of Technology, 310014, Hangzhou, P. R. China.
Chem Biodivers ; 19(6): e202200207, 2022 Jun.
Article em En | MEDLINE | ID: mdl-35419971
ABSTRACT
Two new austocystin analogs, austocystin P (1) and austocystin Q (2), along with fourteen known compounds (3-16) were isolated from the fermentation extract of Aspergillus sp. WHUF05236. The planar structures of 1 and 2 were elucidated through 1D, 2D NMR and MS analyses. Their absolute configurations were determined by the time-dependent density functional (TDDFT)-ECD calculation. Compounds 3, 11, and 12 exhibited antimicrobial activities against Helicobacter pylori with MIC values ranging from 20.00 to 43.47 µM. Compounds 3, 6, and 7 showed cytotoxicities against the human colon cancer cell lines Hct-116 with IC50 values of 101.79, 65.46, and 36.72 µM, respectively.
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aspergillus / Fungos Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aspergillus / Fungos Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article