Advances in mass spectrometry-based epitope mapping of protein therapeutics.

Liu, Xiaoran Roger; Huang, Richard Y-C; Zhao, Feifei; Chen, Guodong; Tao, Li

Liu, Xiaoran Roger; Huang, Richard Y-C; Zhao, Feifei; Chen, Guodong; Tao, Li.

Afiliação

Liu XR; Process Development Analytics, Biologics Development, Global Product Development and Supply, Bristol Myers Squibb, Devens, MA, USA.
Huang RY; Pharmaceutical Candidate Optimization, Nonclinical Research and Development, Bristol Myers Squibb, Princeton, NJ, USA.
Zhao F; Analytical Development and Attribute Sciences, Biologics Development, Global Product Development and Supply, Bristol Myers Squibb, New Brunswick, NJ, USA.
Chen G; Analytical Development and Attribute Sciences, Biologics Development, Global Product Development and Supply, Bristol Myers Squibb, New Brunswick, NJ, USA. Electronic address: Guodong.chen@bms.com.
Tao L; Analytical Development and Attribute Sciences, Biologics Development, Global Product Development and Supply, Bristol Myers Squibb, New Brunswick, NJ, USA.

J Pharm Biomed Anal ; 215: 114754, 2022 Jun 05.

Article em En | MEDLINE | ID: mdl-35427962

Assuntos

Anticorpos Monoclonais; Medição da Troca de Deutério; Anticorpos Monoclonais/química; Deutério; Medição da Troca de Deutério/métodos; Mapeamento de Epitopos/métodos; Espectrometria de Massas/métodos; Solventes

Palavras-chave

Chemical cross-linking; Epitope mapping; Fast photochemical oxidation of proteins; Glycine ethyl ester labeling; Hydrogen/deuterium exchange; Mass spectrometry

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Medição da Troca de Deutério / Anticorpos Monoclonais Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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