Interplay of Anion-π+ and π+ -π+ Interactions in Novel Pyrido[2,1-a]isoquinolinium-Based AIEgens - Substituent- and Counterion-Dependent Fluorescence Modulation and Applications in Live Cell Mitochondrial Imaging.
Chemistry
; 28(38): e202200632, 2022 Jul 06.
Article
em En
| MEDLINE
| ID: mdl-35429368
ABSTRACT
Recently, the concept of anion-π+ interactions has witnessed unique applications in the field of AIEgen development. In this contribution, we disclose a consolidated study of a library of N-doped ionic AIEgens accessed through silver-mediated cyclization of pyridino-alkynes. A thorough photophysical, computational and crystallographic study has been conducted to rationalize the observed substituent- and counterion-dependent fluorescence properties of these luminogens. We further elucidate the prominent role of anion-π+ interactions, π+ -π+ interactions and other non-covalent interactions, in inhibiting the undesired ACQ effect. Finally, we have also demonstrated the application of selected AIEgens for imaging of mitochondria in live cells.
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Base de dados:
MEDLINE
Assunto principal:
Corantes Fluorescentes
/
Mitocôndrias
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article