Exosomes derived from NGF-overexpressing bone marrow mesenchymal stem cell sheet promote spinal cord injury repair in a mouse model.

Li, Siqiaozhi; Liao, Xin; He, Yixuan; Chen, Rui; Zheng, Wei V; Tang, Manshu; Guo, Xiaohua; Chen, Junhui; Hu, Sean; Sun, Jia

Li, Siqiaozhi; Liao, Xin; He, Yixuan; Chen, Rui; Zheng, Wei V; Tang, Manshu; Guo, Xiaohua; Chen, Junhui; Hu, Sean; Sun, Jia.

Afiliação

Li S; Shenzhen Beike Biotechnology Research Institute, Shenzhen, 518057, PR China.
Liao X; Shenzhen Toyon Biotechnology Co.,Ltd, Shenzhen, 518057, PR China.
He Y; Shenzhen Beike Biotechnology Research Institute, Shenzhen, 518057, PR China.
Chen R; Shenzhen Beike Biotechnology Research Institute, Shenzhen, 518057, PR China.
Zheng WV; Intervention and Cell Therapy Center, Shenzhen Hospital of Peking University, Shenzhen, 518057, PR China.
Tang M; Shenzhen Toyon Biotechnology Co.,Ltd, Shenzhen, 518057, PR China.
Guo X; Department of Nephrology, Southern Medical University, Shenzhen Hospital, Shenzhen, 518057, PR China.
Chen J; Intervention and Cell Therapy Center, Shenzhen Hospital of Peking University, Shenzhen, 518057, PR China.
Hu S; Shenzhen Beike Biotechnology Research Institute, Shenzhen, 518057, PR China; Shenzhen Toyon Biotechnology Co.,Ltd, Shenzhen, 518057, PR China. Electronic address: junyuanhu0507res@163.com.
Sun J; Shenzhen Beike Biotechnology Research Institute, Shenzhen, 518057, PR China; Intervention and Cell Therapy Center, Shenzhen Hospital of Peking University, Shenzhen, 518057, PR China. Electronic address: spindriftesj@126.com.

Neurochem Int ; 157: 105339, 2022 07.

Article em En | MEDLINE | ID: mdl-35429578

Assuntos

Exossomos; Células-Tronco Mesenquimais; Traumatismos da Medula Espinal; Animais; Medula Óssea/metabolismo; Modelos Animais de Doenças; Exossomos/metabolismo; Células-Tronco Mesenquimais/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; Fator de Crescimento Neural/metabolismo; Medula Espinal/metabolismo; Traumatismos da Medula Espinal/metabolismo; Traumatismos da Medula Espinal/terapia

Palavras-chave

Axonal regeneration; Bone marrow mesenchymal stem cell sheet; Differentiation; Exosomes; NGF; Neural stem cells; Repair; Spinal cord injury

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Traumatismos da Medula Espinal / Exossomos / Células-Tronco Mesenquimais Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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