STIM1 is the key that unlocks airway smooth muscle remodeling and hyperresponsiveness during asthma.
Cell Calcium
; 104: 102589, 2022 06.
Article
em En
| MEDLINE
| ID: mdl-35430405
ABSTRACT
Airway smooth muscle remodeling and hyperresponsiveness are critical determinants of asthma severity, but the precise mechanisms regulating these disease processes remain elusive. In their latest study published in PNAS, Trebak and colleagues demonstrate that STIM1 (stromal-interacting molecule 1) expression is upregulated in airway smooth muscle cells during asthma and facilitates Ca2+ influx to drive airway remodeling and hyperresponsiveness.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Asma
/
Remodelação das Vias Aéreas
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article