Metronidazole, acyclovir and tetrahydrobiopterin may be promising to treat COVID-19 patients, through interaction with interleukin-12.

Farasati Far, Bahareh; Bokov, Dmitry; Widjaja, Gunawan; Setia Budi, Hendrik; Kamal Abdelbasset, Walid; Javanshir, Shahrzad; Seif, Farhad; Pazoki-Toroudi, Hamidreza; Dey, Sanjay Kumar

Farasati Far, Bahareh; Bokov, Dmitry; Widjaja, Gunawan; Setia Budi, Hendrik; Kamal Abdelbasset, Walid; Javanshir, Shahrzad; Seif, Farhad; Pazoki-Toroudi, Hamidreza; Dey, Sanjay Kumar.

Afiliação

Farasati Far B; Heterocyclic Chemistry Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, Iran.
Bokov D; Institute of Pharmacy, Sechenov First Moscow State Medical University, Moscow, Russian Federation.
Widjaja G; Laboratory of Food Chemistry, Federal Research Center of Nutrition, Biotechnology and Food Safety, Moscow, Russian Federation.
Setia Budi H; Faculty of Public Health, Universitas Indonesia, Depok, Indonesia.
Kamal Abdelbasset W; Department of Oral Biology, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Javanshir S; Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al Kharj, Saudi Arabia.
Seif F; Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt.
Pazoki-Toroudi H; Heterocyclic Chemistry Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, Iran.
Dey SK; Department of Immunology & Allergy, Academic Center for Education, Culture, and Research, Tehran, Iran.

J Biomol Struct Dyn ; 41(10): 4253-4271, 2023 Jul.

Article em En | MEDLINE | ID: mdl-35446232

Assuntos

COVID-19; Metronidazol; Humanos; Metronidazol/farmacologia; Metronidazol/uso terapêutico; Metronidazol/química; Interleucina-12; Simulação de Acoplamento Molecular; Citocinas

Palavras-chave

COVID-19; IL-12; IL-12 receptor; acyclovir; cytokine inhibition; cytokine storm; metronidazole; tetrahydrobiopterin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: COVID-19 / Metronidazol Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: COVID-19 / Metronidazol Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article