Pediatric Astrocytomas and Their Association With Polymorphisms in Embryonic Stem Cell Marker Genes.
J Child Neurol
; 37(6): 534-540, 2022 05.
Article
em En
| MEDLINE
| ID: mdl-35450457
ABSTRACT
BACKGROUND:
Embryonic stem cell markers, such as SOX2, NANOG, and OCT4, are transcription factors expressed in pluripotent stem cells, involved in the mediation of pluripotency and self-renewal. Especially after the discovery of cancer stem cells, these proteins have been associated with several types of neoplasia, including astrocytomas. In the pediatric population, astrocytomas are the most common solid neoplasia and present the highest mortality rates.METHODS:
Our study evaluated 5 polymorphisms in SOX2, NANOG, and POU5F1 genes in 101 pediatric astrocytoma samples.RESULTS:
We describe the associations between wild and polymorphic alleles in astrocytomas.CONCLUSIONS:
In our results, the intronic polymorphic G allele in SOX2 rs77677339 [G/A] had a borderline association with low-grade astrocytomas, and the intronic polymorphic T allele in NANOG rs10845877 [C/T] showed a higher frequency in grade 2, compared to grade 1 astrocytomas, thus showing promising results. IMPACT Our study is relevant because it shows a potential correlation between polymorphic embryonic stem cell marker genes and pediatric astrocytomas.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Astrocitoma
/
Fatores de Transcrição SOXB1
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Proteína Homeobox Nanog
Tipo de estudo:
Risk_factors_studies
Limite:
Child
/
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article