Failed regeneration and inflammation in schizophrenia: two sides of the same coin?
J Neural Transm (Vienna)
; 129(5-6): 611-615, 2022 06.
Article
em En
| MEDLINE
| ID: mdl-35451657
ABSTRACT
More than 100 years after its conceptual definition as 'Dementia Praecox' by Emil Kraepelin, which was changed to schizophrenia by Eugen Bleuler, this is still a serious and debilitating psychiatric illness. The neurodevelopmental hypothesis of schizophrenia, introduced more than 30 years ago, states that schizophrenia is a consequence of failed neurodevelopmental processes leading to a dysfunctional neuronal network forming the basis for a psychosis proneness. Subsequently, significant research efforts were made to prove the neurodevelopmental or the neurodegenerative perspective. This review summarizes key arguments speaking for or against the two hypotheses leading to a concept with both aspects position side by side.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Transtornos Psicóticos
/
Esquizofrenia
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article