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Preparation of Chitosan/Clay Composites for Safe and Effective Hemorrhage Control.
Yang, Zhiyuan; Ye, Tong; Ma, Fei; Zhao, Xinhong; Yang, Lei; Dou, Guifang; Gan, Hui; Wu, Zhuona; Zhu, Xiaoxia; Gu, Ruolan; Meng, Zhiyun.
Afiliação
  • Yang Z; College of pharmacy, Henan University, Kaifeng 475000, China.
  • Ye T; Beijing Institute of Radiation Medicine, Beijing 100850, China.
  • Ma F; Beijing Institute of Radiation Medicine, Beijing 100850, China.
  • Zhao X; Beijing Institute of Radiation Medicine, Beijing 100850, China.
  • Yang L; Beijing Institute of Radiation Medicine, Beijing 100850, China.
  • Dou G; Beijing Institute of Radiation Medicine, Beijing 100850, China.
  • Gan H; College of pharmacy, Henan University, Kaifeng 475000, China.
  • Wu Z; Beijing Institute of Radiation Medicine, Beijing 100850, China.
  • Zhu X; Beijing Institute of Radiation Medicine, Beijing 100850, China.
  • Gu R; Beijing Institute of Radiation Medicine, Beijing 100850, China.
  • Meng Z; Beijing Institute of Radiation Medicine, Beijing 100850, China.
Molecules ; 27(8)2022 Apr 15.
Article em En | MEDLINE | ID: mdl-35458768
ABSTRACT
Uncontrolled hemorrhage from trauma or surgery can lead to death. In this study, chitosan/kaolin (CSK) and chitosan/montmorillonite (CSMMT) composites were prepared from chitosan (CS), kaolin (K), and montmorillonite (MMT) as raw materials to control bleeding. The physiochemical properties and surface morphology of CSK and CSMMT composites were analyzed by Fourier transform infrared spectrometry (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), zeta potentials, and X-ray fluorescence (XRF). The hemostatic mechanism was measured in vitro by activated partial thromboplastin time (APTT), prothrombin time (PT), in vitro clotting time, erythrocyte aggregation, and thromboelastogram (TEG). The hemostasis ability was further verified by using tail amputation and arteriovenous injury models in rats. The biocompatibility of CSK and CSMMT was evaluated by in vitro hemolysis, cytotoxicity assays, as well as acute toxicity test and skin irritation tests. The results show that CSK and CSMMT are promising composite materials with excellent biocompatibility and hemostatic properties that can effectively control bleeding.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hemostáticos / Quitosana Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hemostáticos / Quitosana Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article