Organization and expression of the mammalian mitochondrial genome.
Nat Rev Genet
; 23(10): 606-623, 2022 10.
Article
em En
| MEDLINE
| ID: mdl-35459860
ABSTRACT
The mitochondrial genome encodes core subunits of the respiratory chain that drives oxidative phosphorylation and is, therefore, essential for energy conversion. Advances in high-throughput sequencing technologies and cryoelectron microscopy have shed light on the structure and organization of the mitochondrial genome and revealed unique mechanisms of mitochondrial gene regulation. New animal models of impaired mitochondrial protein synthesis have shown how the coordinated regulation of the cytoplasmic and mitochondrial translation machineries ensures the correct assembly of the respiratory chain complexes. These new technologies and disease models are providing a deeper understanding of mitochondrial genome organization and expression and of the diseases caused by impaired energy conversion, including mitochondrial, neurodegenerative, cardiovascular and metabolic diseases. They also provide avenues for the development of treatments for these conditions.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Genoma Mitocondrial
Limite:
Animals
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article