Structure-activity relationships of 1,4-bis(arylsulfonamido)-benzene or naphthalene-N,N'-diacetic acids with varying C2-substituents as inhibitors of Keap1-Nrf2 protein-protein interaction.

Lee, Sumi; Abed, Dhulfiqar Ali; Nguyen, Mai-Uyen; Verzi, Michael P; Hu, Longqin

Lee, Sumi; Abed, Dhulfiqar Ali; Nguyen, Mai-Uyen; Verzi, Michael P; Hu, Longqin.

Afiliação

Lee S; Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ, 08854, United States.
Abed DA; Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ, 08854, United States.
Nguyen MU; Department of Genetics, Human Genetics Institute of New Jersey, Rutgers, The State University of New Jersey, Life Sciences Building, 145 Bevier Road, Piscataway, NJ, 08854, United States.
Verzi MP; Department of Genetics, Human Genetics Institute of New Jersey, Rutgers, The State University of New Jersey, Life Sciences Building, 145 Bevier Road, Piscataway, NJ, 08854, United States; Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, 08901, United States.
Hu L; Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ, 08854, United States; Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, 08901, United States. Electronic address: LongHu@pharmacy.rutgers.

Eur J Med Chem ; 237: 114380, 2022 Jul 05.

Article em En | MEDLINE | ID: mdl-35462166

Assuntos

Benzeno; Fator 2 Relacionado a NF-E2; Benzeno/química; Benzeno/farmacologia; Proteína 1 Associada a ECH Semelhante a Kelch/metabolismo; Naftalenos/química; Naftalenos/farmacologia; Fator 2 Relacionado a NF-E2/metabolismo; Ligação Proteica; Relação Estrutura-Atividade; Estresse Oxidativo

Palavras-chave

Keap1; Keap1-Nrf2 interaction; Nrf2; Oxidative stress; Protein-protein interaction inhibitor; Structural diversity; Structure-activity relationship

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Benzeno / Fator 2 Relacionado a NF-E2 Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Benzeno / Fator 2 Relacionado a NF-E2 Idioma: En Ano de publicação: 2022 Tipo de documento: Article