Docosahexaenoic acid and eicosapentaenoic acid strongly inhibit prostanoid TP receptor-dependent contractions of guinea pig gastric fundus smooth muscle.

Xu, Keyue; Shimizu, Miyuki; Murai, Chika; Fujisawa, Miki; Ito, Daichi; Saitoh, Noboru; Nakagome, Yutaka; Yamashita, Mio; Murata, Azusa; Oikawa, Shunya; Ou, Guanghan; Yoshioka, Kento; Obara, Keisuke; Tanaka, Yoshio

Xu, Keyue; Shimizu, Miyuki; Murai, Chika; Fujisawa, Miki; Ito, Daichi; Saitoh, Noboru; Nakagome, Yutaka; Yamashita, Mio; Murata, Azusa; Oikawa, Shunya; Ou, Guanghan; Yoshioka, Kento; Obara, Keisuke; Tanaka, Yoshio.

Afiliação

Xu K; Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi-City, Chiba, Japan.
Shimizu M; Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi-City, Chiba, Japan.
Murai C; Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi-City, Chiba, Japan.
Fujisawa M; Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi-City, Chiba, Japan.
Ito D; Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi-City, Chiba, Japan.
Saitoh N; Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi-City, Chiba, Japan.
Nakagome Y; Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi-City, Chiba, Japan.
Yamashita M; Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi-City, Chiba, Japan.
Murata A; Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi-City, Chiba, Japan.
Oikawa S; Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi-City, Chiba, Japan.
Ou G; Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi-City, Chiba, Japan.
Yoshioka K; Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi-City, Chiba, Japan.
Obara K; Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi-City, Chiba, Japan.
Tanaka Y; Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi-City, Chiba, Japan.

Pharmacol Res Perspect ; 10(3): e00952, 2022 06.

Article em En | MEDLINE | ID: mdl-35466586

Assuntos

Ácidos Docosa-Hexaenoicos; Ácido Eicosapentaenoico; Ácido 15-Hidroxi-11 alfa,9 alfa-(epoximetano)prosta-5,13-dienoico/metabolismo; Ácido 15-Hidroxi-11 alfa,9 alfa-(epoximetano)prosta-5,13-dienoico/farmacologia; Animais; Canais de Cálcio Tipo L/metabolismo; Ácidos Docosa-Hexaenoicos/metabolismo; Ácidos Docosa-Hexaenoicos/farmacologia; Ácido Eicosapentaenoico/metabolismo; Ácido Eicosapentaenoico/farmacologia; Fundo Gástrico/metabolismo; Cobaias; Músculo Liso; Prostaglandinas/metabolismo; Prostaglandinas/farmacologia; RNA Mensageiro/metabolismo; Receptores de Tromboxanos/metabolismo; Verapamil/metabolismo; Verapamil/farmacologia

Palavras-chave

docosahexaenoic acid; eicosapentaenoic acid; gastric fundus smooth muscle; n−3 polyunsaturated fatty acids; prostanoid TP receptor; prostanoids

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácido Eicosapentaenoico / Ácidos Docosa-Hexaenoicos Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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