EGFR suppresses p53 function by promoting p53 binding to DNA-PKcs: a noncanonical regulatory axis between EGFR and wild-type p53 in glioblastoma.

Ding, Jie; Li, Xiaolong; Khan, Sabbir; Zhang, Chen; Gao, Feng; Sen, Shayak; Wasylishen, Amanda R; Zhao, Yang; Lozano, Guillermina; Koul, Dimpy; Alfred Yung, W K

Ding, Jie; Li, Xiaolong; Khan, Sabbir; Zhang, Chen; Gao, Feng; Sen, Shayak; Wasylishen, Amanda R; Zhao, Yang; Lozano, Guillermina; Koul, Dimpy; Alfred Yung, W K.

Afiliação

Ding J; Department of Neuro-Oncology, Brain Tumor Center, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Li X; Department of Neuro-Oncology, Brain Tumor Center, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Khan S; Department of Neuro-Oncology, Brain Tumor Center, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Zhang C; Department of Neuro-Oncology, Brain Tumor Center, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Gao F; Department of Neuro-Oncology, Brain Tumor Center, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Sen S; Department of Neuro-Oncology, Brain Tumor Center, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Wasylishen AR; Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Zhao Y; Department of Dermatology, Stanford University School of Medicine, Stanford, California, USA.
Lozano G; Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Koul D; Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Alfred Yung WK; UTHealth Graduate School of Biomedical Sciences, Houston, Texas, USA.

Neuro Oncol ; 24(10): 1712-1725, 2022 10 03.

Article em En | MEDLINE | ID: mdl-35474131

Assuntos

Glioblastoma; Glioma; Animais; DNA; Proteína Quinase Ativada por DNA/genética; Proteína Quinase Ativada por DNA/metabolismo; Receptores ErbB/genética; Receptores ErbB/metabolismo; Glioblastoma/metabolismo; Camundongos; Piridazinas; Quinazolinas; RNA Interferente Pequeno; Espécies Reativas de Oxigênio/metabolismo; Proteína Supressora de Tumor p53/genética; Proteína Supressora de Tumor p53/metabolismo

Palavras-chave

DNA-PKcs; EGFR; glioblastoma; wt-p53

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Glioblastoma / Glioma Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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