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Mild Three-Step Consecutive C-H Activations.
Liu, Yao-Yao; Qu, Yuan-Lu; Kang, Yan-Shang; Zhu, Yue-Lu; Sun, Wei-Yin; Lu, Yi.
Afiliação
  • Liu YY; Coordination Chemistry Institute, State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing National Laboratory of Microstructures, Collaborative Innovation Center of Advanced Micro-structures, Nanjing University, Nanjing 210023, China.
  • Qu YL; Coordination Chemistry Institute, State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing National Laboratory of Microstructures, Collaborative Innovation Center of Advanced Micro-structures, Nanjing University, Nanjing 210023, China.
  • Kang YS; Coordination Chemistry Institute, State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing National Laboratory of Microstructures, Collaborative Innovation Center of Advanced Micro-structures, Nanjing University, Nanjing 210023, China.
  • Zhu YL; Coordination Chemistry Institute, State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing National Laboratory of Microstructures, Collaborative Innovation Center of Advanced Micro-structures, Nanjing University, Nanjing 210023, China.
  • Sun WY; Coordination Chemistry Institute, State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing National Laboratory of Microstructures, Collaborative Innovation Center of Advanced Micro-structures, Nanjing University, Nanjing 210023, China.
  • Lu Y; Coordination Chemistry Institute, State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing National Laboratory of Microstructures, Collaborative Innovation Center of Advanced Micro-structures, Nanjing University, Nanjing 210023, China.
Org Lett ; 24(17): 3118-3122, 2022 05 06.
Article em En | MEDLINE | ID: mdl-35475650
ABSTRACT
Herein, the Rh-catalyzed consecutive C-H bond olefination/annulation/olefination cascade, tandemly directed by sulfonamide and ester groups, has been developed under mild conditions with the assistance of 1-adamantane carboxylic acid. A seven-membered metallacycle including an ester group was preferred to the five-membered one including a sulfonamide group for the third C-H activation. In this transformation, the Rh catalyst exhibits its high reactivity by catalyzing a triple C-H activation process with a low catalyst loading at 50 °C. This method can be applied in the construction of various pharmaceutical derivatives.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ródio Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ródio Idioma: En Ano de publicação: 2022 Tipo de documento: Article