Synthesis of Substituted 2-Pyridones via 6π-Electrocyclization of Dienyl Isocyanates.
J Org Chem
; 87(9): 6403-6409, 2022 05 06.
Article
em En
| MEDLINE
| ID: mdl-35476425
ABSTRACT
A one-pot Curtius rearrangement of dienyl carboxylic acids followed by a 6π-electrocyclization process to form substituted 2-pyridone products has been developed. Dienyl isocyanates generated from aliphatic acids were more reactive than their aromatic counterparts. Additionally, substitution patterns of the carboxylic acids had an impact on the efficiency of the cyclization.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Piridonas
/
Isocianatos
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article