A walk through the SMC cycle: From catching DNAs to shaping the genome.
Mol Cell
; 82(9): 1616-1630, 2022 05 05.
Article
em En
| MEDLINE
| ID: mdl-35477004
ABSTRACT
SMC protein complexes are molecular machines that provide structure to chromosomes. These complexes bridge DNA elements and by doing so build DNA loops in cis and hold together the sister chromatids in trans. We discuss how drastic conformational changes allow SMC complexes to build such intricate DNA structures. The tight regulation of these complexes controls fundamental chromosomal processes such as transcription, recombination, repair, and mitosis.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas Cromossômicas não Histona
/
Proteínas de Ciclo Celular
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article