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Ancestry-inclusive dog genomics challenges popular breed stereotypes.
Morrill, Kathleen; Hekman, Jessica; Li, Xue; McClure, Jesse; Logan, Brittney; Goodman, Linda; Gao, Mingshi; Dong, Yinan; Alonso, Marjie; Carmichael, Elena; Snyder-Mackler, Noah; Alonso, Jacob; Noh, Hyun Ji; Johnson, Jeremy; Koltookian, Michele; Lieu, Charlie; Megquier, Kate; Swofford, Ross; Turner-Maier, Jason; White, Michelle E; Weng, Zhiping; Colubri, Andrés; Genereux, Diane P; Lord, Kathryn A; Karlsson, Elinor K.
Afiliação
  • Morrill K; Bioinformatics and Integrative Biology, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.
  • Hekman J; Morningside Graduate School of Biomedical Sciences, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.
  • Li X; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • McClure J; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Logan B; Bioinformatics and Integrative Biology, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.
  • Goodman L; Morningside Graduate School of Biomedical Sciences, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.
  • Gao M; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Dong Y; Bioinformatics and Integrative Biology, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.
  • Alonso M; Bioinformatics and Integrative Biology, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.
  • Carmichael E; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Snyder-Mackler N; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Alonso J; Fauna Bio Inc., Emeryville, CA 94608, USA.
  • Noh HJ; Bioinformatics and Integrative Biology, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.
  • Johnson J; Morningside Graduate School of Biomedical Sciences, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.
  • Koltookian M; Bioinformatics and Integrative Biology, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.
  • Lieu C; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Megquier K; The International Association of Animal Behavior Consultants, Cranberry Township, PA 16066, USA.
  • Swofford R; IAABC Foundation, Cranberry Township, PA 16066, USA.
  • Turner-Maier J; Bioinformatics and Integrative Biology, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.
  • White ME; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Weng Z; Rice University, Houston, TX 77005, USA.
  • Colubri A; Center for Evolution and Medicine, Arizona State University, Tempe, AZ 85251, USA.
  • Genereux DP; School for Human Evolution and Social Change, Arizona State University, Tempe, AZ 85251, USA.
  • Lord KA; School of Life Sciences, Arizona State University, Tempe, AZ 85251, USA.
  • Karlsson EK; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Science ; 376(6592): eabk0639, 2022 04 29.
Article em En | MEDLINE | ID: mdl-35482869
ABSTRACT
Behavioral genetics in dogs has focused on modern breeds, which are isolated subgroups with distinctive physical and, purportedly, behavioral characteristics. We interrogated breed stereotypes by surveying owners of 18,385 purebred and mixed-breed dogs and genotyping 2155 dogs. Most behavioral traits are heritable [heritability (h2) > 25%], and admixture patterns in mixed-breed dogs reveal breed propensities. Breed explains just 9% of behavioral variation in individuals. Genome-wide association analyses identify 11 loci that are significantly associated with behavior, and characteristic breed behaviors exhibit genetic complexity. Behavioral loci are not unusually differentiated in breeds, but breed propensities align, albeit weakly, with ancestral function. We propose that behaviors perceived as characteristic of modern breeds derive from thousands of years of polygenic adaptation that predates breed formation, with modern breeds distinguished primarily by aesthetic traits.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Genômica / Estudo de Associação Genômica Ampla Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Genômica / Estudo de Associação Genômica Ampla Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article