EPO synthesis induced by HIF-PHD inhibition is dependent on myofibroblast transdifferentiation and colocalizes with non-injured nephron segments in murine kidney fibrosis.

Kobayashi, Hanako; Davidoff, Olena; Pujari-Palmer, Shiuli; Drevin, Malin; Haase, Volker H

Kobayashi, Hanako; Davidoff, Olena; Pujari-Palmer, Shiuli; Drevin, Malin; Haase, Volker H.

Afiliação

Kobayashi H; Department of Medicine, Vanderbilt University Medical Center and Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Davidoff O; Medical and Research Services, Department of Veterans Affairs Hospital, Tennessee Valley Healthcare System, Nashville, Tennessee, USA.
Pujari-Palmer S; Department of Medicine, Vanderbilt University Medical Center and Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Drevin M; Medical and Research Services, Department of Veterans Affairs Hospital, Tennessee Valley Healthcare System, Nashville, Tennessee, USA.
Haase VH; MAIIA Diagnostics, Uppsala, Sweden.

Acta Physiol (Oxf) ; 235(4): e13826, 2022 08.

Article em En | MEDLINE | ID: mdl-35491502

Assuntos

Eritropoetina; Insuficiência Renal Crônica; Animais; Transdiferenciação Celular; Eritropoetina/farmacologia; Fibrose; Prolina Dioxigenases do Fator Induzível por Hipóxia; Rim; Camundongos; Camundongos Knockout; Miofibroblastos; Néfrons; Prolil Hidroxilases; Insuficiência Renal Crônica/complicações

Palavras-chave

anemia; chronic kidney disease; erythropoietin; hypoxia-inducible factor; molidustat; prolyl hydroxylase domain

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Eritropoetina / Insuficiência Renal Crônica Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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