Proanthocyanidins inhibit the apoptosis and aging of nucleus pulposus cells through the PI3K/Akt pathway delaying intervertebral disc degeneration.

Chen, Hai-Wei; Liu, Ming-Qiang; Zhang, Guang-Zhi; Zhang, Cang-Yu; Wang, Zhao-Heng; Lin, Ai-Xin; Kang, Ji-He; Liu, Wen-Zhao; Guo, Xu-Dong; Wang, Yi-Dian; Kang, Xue-Wen

Chen, Hai-Wei; Liu, Ming-Qiang; Zhang, Guang-Zhi; Zhang, Cang-Yu; Wang, Zhao-Heng; Lin, Ai-Xin; Kang, Ji-He; Liu, Wen-Zhao; Guo, Xu-Dong; Wang, Yi-Dian; Kang, Xue-Wen.

Afiliação

Chen HW; Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou, Gansu, China.
Liu MQ; The Second Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.
Zhang GZ; Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou, Gansu, China.
Zhang CY; The Second Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.
Wang ZH; Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou, Gansu, China.
Lin AX; The Second Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.
Kang JH; Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou, Gansu, China.
Liu WZ; The Second Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.
Guo XD; Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou, Gansu, China.
Wang YD; The Second Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.
Kang XW; Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou, Gansu, China.

Connect Tissue Res ; 63(6): 650-662, 2022 11.

Article em En | MEDLINE | ID: mdl-35491814

Assuntos

Degeneração do Disco Intervertebral; Disco Intervertebral; Núcleo Pulposo; Proantocianidinas; Envelhecimento; Caspase 3/metabolismo; Caspase 9/metabolismo; Caspase 9/farmacologia; Células Cultivadas; Humanos; Disco Intervertebral/patologia; Degeneração do Disco Intervertebral/patologia; Núcleo Pulposo/patologia; Fosfatidilinositol 3-Quinases/metabolismo; Proantocianidinas/metabolismo; Proantocianidinas/farmacologia; Proantocianidinas/uso terapêutico; Proteínas Proto-Oncogênicas c-akt/metabolismo; Proteínas Proto-Oncogênicas c-bcl-2/metabolismo; Qualidade de Vida; Proteína Supressora de Tumor p53/metabolismo; Proteína Supressora de Tumor p53/farmacologia; Proteína Supressora de Tumor p53/uso terapêutico; Proteína X Associada a bcl-2/metabolismo; Proteína X Associada a bcl-2/farmacologia

Palavras-chave

Proanthocyanidins; aging; apoptosis; intervertebral disc degeneration; nucleus pulposus cells

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proantocianidinas / Degeneração do Disco Intervertebral / Núcleo Pulposo / Disco Intervertebral Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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