Electro-oxidative cyclization: access to quinazolinones via K2S2O8 without transition metal catalyst and base.
RSC Adv
; 11(50): 31650-31655, 2021 Sep 21.
Article
em En
| MEDLINE
| ID: mdl-35496883
ABSTRACT
A K2S2O8-promoted oxidative tandem cyclization of primary alcohols with 2-aminobenzamides to synthesize quinazolinones was successfully achieved under undivided electrolytic conditions without a transition metal and base. The key feature of this protocol is the utilization of K2S2O8 as an inexpensive and easy-to-handle radical surrogate that can effectively promote the reaction via a simple procedure, leading to the formation of nitrogen heterocycles via direct oxidative cyclization at room temperature in a one-pot procedure under constant current. Owing to the use of continuous-flow electrochemical setups, this green, mild and practical electrosynthesis features high efficiency and excellent functional group tolerance and is easy to scale up.
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Base de dados:
MEDLINE
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Guideline
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article