Engineering pH-responsive switching of donor-π-acceptor chromophore alignments along a peptide nanotube scaffold.
RSC Adv
; 10(6): 3588-3592, 2020 Jan 16.
Article
em En
| MEDLINE
| ID: mdl-35497746
ABSTRACT
A cyclic tri-ß-peptide cyclo(ß-Ala-ß-Ala-ß-Lys) having diethylaminonaphthalimide at the ß-Lys side chain (CP3Npi) self-assembled into a peptide nanotube in a solution of HFIP and water. CD spectra of the CP3Npi nanotubes show a negative Cotton effect at 441 nm and a positive Cotton effect at 393 nm, indicating that D-π-A naphthalimide chromophores are aligned in a left-handed chiral way along the nanotube. The CP3Npi nanotubes bear positive charges under acidic conditions retaining the nanotube structure but pH-responsive switching of D-π-A naphthalimide alignments along the nanotube between a left-handed chiral and random arrangement was observed. The peptide nanotube is a stable scaffold for attaining pH-responsive alignment switching of side-chain chromophores.
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MEDLINE
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En
Ano de publicação:
2020
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Article