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Thiopurine Enhanced ALL Maintenance (TEAM): study protocol for a randomized study to evaluate the improvement in disease-free survival by adding very low dose 6-thioguanine to 6-mercaptopurine/methotrexate-based maintenance therapy in pediatric and adult patients (0-45 years) with newly diagnosed B-cell precursor or T-cell acute lymphoblastic leukemia treated according to the intermediate risk-high group of the ALLTogether1 protocol.
Toksvang, Linea Natalie; Als-Nielsen, Bodil; Bacon, Christopher; Bertasiute, Ruta; Duarte, Ximo; Escherich, Gabriele; Helgadottir, Elín Anna; Johannsdottir, Inga Rinvoll; Jónsson, Ólafur G; Kozlowski, Piotr; Langenskjöld, Cecilia; Lepik, Kristi; Niinimäki, Riitta; Overgaard, Ulrik Malthe; Punab, Mari; Räty, Riikka; Segers, Heidi; van der Sluis, Inge; Smith, Owen Patrick; Strullu, Marion; Vaitkeviciene, Goda; Wik, Hilde Skuterud; Heyman, Mats; Schmiegelow, Kjeld.
Afiliação
  • Toksvang LN; Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark. Linea.natalie.toksvang@regionh.dk.
  • Als-Nielsen B; Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark.
  • Bacon C; St. James Hospital, Dublin, Ireland.
  • Bertasiute R; Vilnius University Hospital Santariskiu Klinikos, Vilnius, Lithuania.
  • Duarte X; Instituto Português de Oncologia Lisboa Francisco Gentil Departamento de Pediatria, Lisbon, Portugal.
  • Escherich G; University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Helgadottir EA; Landspitali University Hospital, Reykjavik, Iceland.
  • Johannsdottir IR; Oslo University Hospital, Oslo, Norway.
  • Jónsson ÓG; Landspitali University Hospital, Reykjavik, Iceland.
  • Kozlowski P; Örebro University Hospital, Örebro, Sweden.
  • Langenskjöld C; Drottning Silvias Barnsjukhus, Gothenburg, Sweden.
  • Lepik K; Tallinn Children's Hospital, Tallinn, Estonia.
  • Niinimäki R; Oulu University Hospital and PEDEGRO Research Unit, University of Oulu, Oulu, Finland.
  • Overgaard UM; Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
  • Punab M; Tartu University Hospital, Tartu, Estonia.
  • Räty R; Helsinki University Central Hospital, Helsinki, Finland.
  • Segers H; Leuvens Kanker Instituut (LKI), KU Leuven - UZ Leuven, Leuven, Belgium.
  • van der Sluis I; Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands.
  • Smith OP; Our Lady's Children Hospital, Dublin, Ireland.
  • Strullu M; Université de Paris, hôpital universitaire Robert-Debré (APHP), Paris, France.
  • Vaitkeviciene G; Center for Pediatric Oncology and Hematology, Vilnius University, Vilnius, Lithuania.
  • Wik HS; Oslo University Hospital, Oslo, Norway.
  • Heyman M; Karolinska Institutet, Stockholm, Sweden.
  • Schmiegelow K; Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.
BMC Cancer ; 22(1): 483, 2022 May 02.
Article em En | MEDLINE | ID: mdl-35501736
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Texto completo: 1 Eixos temáticos: Pesquisa_clinica Base de dados: MEDLINE Assunto principal: Leucemia-Linfoma Linfoblástico de Células Precursoras / Leucemia-Linfoma Linfoblástico de Células T Precursoras Tipo de estudo: Clinical_trials / Diagnostic_studies / Etiology_studies / Guideline / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Child, preschool / Humans / Infant / Middle aged / Newborn Idioma: En Ano de publicação: 2022 Tipo de documento: Article
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Texto completo: 1 Eixos temáticos: Pesquisa_clinica Base de dados: MEDLINE Assunto principal: Leucemia-Linfoma Linfoblástico de Células Precursoras / Leucemia-Linfoma Linfoblástico de Células T Precursoras Tipo de estudo: Clinical_trials / Diagnostic_studies / Etiology_studies / Guideline / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Child, preschool / Humans / Infant / Middle aged / Newborn Idioma: En Ano de publicação: 2022 Tipo de documento: Article