Alterations in 3D chromatin organization contribute to tumorigenesis of <i>EGFR</i>-amplified glioblastoma.

Alterations in 3D chromatin organization contribute to tumorigenesis of EGFR-amplified glioblastoma.

Yang, Qi; Jiang, Nian; Zou, Han; Fan, Xuning; Liu, Tao; Huang, Xi; Wanggou, Siyi; Li, Xuejun.

Afiliação

Yang Q; Department of Neurosurgery, Xiangya Hospital, Central South University, No. 87, Xiangya Road, Changsha, Hunan 410008, PR China.
Jiang N; Hunan International Scientific and Technological Cooperation Base of Brain Tumor Research, Xiangya Hospital, Central South University, No. 87, Xiangya Road, Changsha, Hunan 410008, PR China.
Zou H; Department of Neurosurgery, Xiangya Hospital, Central South University, No. 87, Xiangya Road, Changsha, Hunan 410008, PR China.
Fan X; Hunan International Scientific and Technological Cooperation Base of Brain Tumor Research, Xiangya Hospital, Central South University, No. 87, Xiangya Road, Changsha, Hunan 410008, PR China.
Liu T; Department of Neurosurgery, Xiangya Hospital, Central South University, No. 87, Xiangya Road, Changsha, Hunan 410008, PR China.
Huang X; Hunan International Scientific and Technological Cooperation Base of Brain Tumor Research, Xiangya Hospital, Central South University, No. 87, Xiangya Road, Changsha, Hunan 410008, PR China.
Wanggou S; Annoroad Gene Tech. (Beijing) Co., Ltd, Block 1, Yard 88, Kechuang 6 RD, Beijing Economic-Technological Development Area, Beijing 100176, PR China.
Li X; Annoroad Gene Tech. (Beijing) Co., Ltd, Block 1, Yard 88, Kechuang 6 RD, Beijing Economic-Technological Development Area, Beijing 100176, PR China.

Comput Struct Biotechnol J ; 20: 1967-1978, 2022.

Article em En | MEDLINE | ID: mdl-35521558

Palavras-chave

3D genomic; Astrocytes; DE, Differentially expressed; FDR, False discovery rate; GBM, Glioblastoma multiform; Glioblastoma; Hi-C; ICE, Iterative correction and eigenvector decomposition; IDE, Distance decay exponent; PCC, Pearson's correlation coefficient; SV, Structure variation; Structure Variation; TAD, Topological associating domain; Tumorigenesis; WGS, Whole-genome sequencing

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article