Regulation of osteogenic differentiation by the pro-inflammatory cytokines IL-1ß and TNF-α: current conclusions and controversies.
Hum Cell
; 35(4): 957-971, 2022 Jul.
Article
em En
| MEDLINE
| ID: mdl-35522425
ABSTRACT
Treatment of complex bone fracture diseases is still a complicated problem that is urged to be solved in orthopedics. In bone tissue engineering, the use of mesenchymal stromal/stem cells (MSCs) for tissue repair brings hope to the medical field of bone diseases. MSCs can differentiate into osteoblasts and promote bone regeneration. An increasing number of studies show that the inflammatory microenvironment affects the osteogenic differentiation of MSCs. It is shown that TNF-α and IL-1ß play different roles in the osteogenic differentiation of MSCs via different signal pathways. The main factors that affect the role of TNF-α and IL-1ß in osteogenic differentiation of MSCs include concentration and the source of stem cells (different species and different tissues). This review in-depth analyzes the roles of pro-inflammatory cytokines in the osteogenic differentiation of MSCs and reveals some current controversies to provide a reference of comprehensively understanding.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Osteogênese
/
Células-Tronco Mesenquimais
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article