Interpretation of changes in coronary flow that accompany pharmacologic interventions.
Circulation
; 75(6 Pt 2): V34-8, 1987 Jun.
Article
em En
| MEDLINE
| ID: mdl-3552315
ABSTRACT
The interpretation of a change in coronary flow that accompanies administration of a calcium-entry blocker or other pharmacologic agent remains complicated by the variety of factors potentially altered by the agent that can themselves affect flow. These factors are reviewed in the context of steady-state coronary pressure-flow relationships, emphasizing the complexities induced by coronary artery disease. Limitations of currently available approaches for the measurement of coronary reserve, examination of flow heterogeneity, and the calculation of coronary vascular resistance are also addressed. Calcium entry-blocking agents have a number of hemodynamic effects that are likely to augment coronary flow favorably. However, parodoxical and potentially deleterious effects on local flow also seem possible in selected situations.
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Base de dados:
MEDLINE
Assunto principal:
Bloqueadores dos Canais de Cálcio
/
Circulação Coronária
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
1987
Tipo de documento:
Article