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Adults hospitalized with breakthrough COVID-19 have lower mortality than matched unvaccinated adults.
Myers, Laura C; Kipnis, Patricia; Greene, John; Lawson, Brian; Escobar, Gabriel J; Fireman, Bruce H; Klein, Nicola P; Liu, Vincent X.
Afiliação
  • Myers LC; Division of Research and The Permanente Medical Group, Kaiser Permanente Northern California, Oakland, California, USA.
  • Kipnis P; Division of Research and The Permanente Medical Group, Kaiser Permanente Northern California, Oakland, California, USA.
  • Greene J; Division of Research and The Permanente Medical Group, Kaiser Permanente Northern California, Oakland, California, USA.
  • Lawson B; Division of Research and The Permanente Medical Group, Kaiser Permanente Northern California, Oakland, California, USA.
  • Escobar GJ; Division of Research and The Permanente Medical Group, Kaiser Permanente Northern California, Oakland, California, USA.
  • Fireman BH; Division of Research and The Permanente Medical Group, Kaiser Permanente Northern California, Oakland, California, USA.
  • Klein NP; Division of Research and The Permanente Medical Group, Kaiser Permanente Northern California, Oakland, California, USA.
  • Liu VX; Division of Research and The Permanente Medical Group, Kaiser Permanente Northern California, Oakland, California, USA.
J Intern Med ; 292(2): 377-384, 2022 08.
Article em En | MEDLINE | ID: mdl-35531712
BACKGROUND: Coronavirus disease 2019 (COVID-19) breakthrough infections are common. OBJECTIVE: Evaluate in-hospital mortality of patients with COVID-19 by vaccination status using retrospective cohort study. METHODS: We generated propensity scores for receipt of full vaccination in adults requiring supplemental oxygen hospitalized at Kaiser Permanente Northern California (1 April 2021 to 30 November 2021) with positive severe acute respiratory syndrome coronavirus 2 polymerase chain reaction tests. Optimal matching of fully vaccinated/unvaccinated patients was performed comparing in-hospital mortality. RESULTS: Of 7305 patients, 1463 (20.0%) were full, 138 (1.9%) were partial, and 5704 (78.1%) were unvaccinated. Fully vaccinated were older than partial or unvaccinated (71.0, 63.0, and 54.0 years, respectively, p < 0.001) with more comorbidities (Comorbidity Point Scores 33.0, 22.0, and 10.0, p < 0.001) and immunosuppressant (11.5%, 8.7%, and 3.0%, p < 0.001) or chemotherapy exposure (2.8%, 0.7%, and 0.4%, p < 0.001). Fewer fully vaccinated patients died compared to matched unvaccinated (9.0% vs. 16.3%, p < 0.0001). CONCLUSION: Fully vaccinated patients are less likely to die compared to matched unvaccinated patients.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: COVID-19 Tipo de estudo: Observational_studies Limite: Adult / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: COVID-19 Tipo de estudo: Observational_studies Limite: Adult / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article