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MicroRNAs in kidney development and disease.
Cerqueira, Débora Malta; Tayeb, Maliha; Ho, Jacqueline.
Afiliação
  • Cerqueira DM; Division of Nephrology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
  • Tayeb M; John G. Rangos Sr. Research Center, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Ho J; Division of Nephrology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
JCI Insight ; 7(9)2022 05 09.
Article em En | MEDLINE | ID: mdl-35531954
ABSTRACT
MicroRNAs (miRNAs) belong to a class of endogenous small noncoding RNAs that regulate gene expression at the posttranscriptional level, through both translational repression and mRNA destabilization. They are key regulators of kidney morphogenesis, modulating diverse biological processes in different renal cell lineages. Dysregulation of miRNA expression disrupts early kidney development and has been implicated in the pathogenesis of developmental kidney diseases. In this Review, we summarize current knowledge of miRNA biogenesis and function and discuss in detail the role of miRNAs in kidney morphogenesis and developmental kidney diseases, including congenital anomalies of the kidney and urinary tract and Wilms tumor. We conclude by discussing the utility of miRNAs as potentially novel biomarkers and therapeutic agents.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tumor de Wilms / MicroRNAs / Neoplasias Renais Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tumor de Wilms / MicroRNAs / Neoplasias Renais Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article