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Synthesis of o-Carborane-Fused Pyrazoles through Sequential C-N Bond Formation.
Maeng, Chanyoung; Ko, Gi Hoon; Yang, Heejin; Han, Sang Hoon; Han, Gi Uk; Chan Noh, Hee; Lee, Kyungsup; Kim, Dongwook; Lee, Phil Ho.
Afiliação
  • Maeng C; Department of Chemistry, Kangwon National University, Chuncheon 24341, Republic of Korea.
  • Ko GH; Department of Chemistry, Kangwon National University, Chuncheon 24341, Republic of Korea.
  • Yang H; Department of Chemistry, Kangwon National University, Chuncheon 24341, Republic of Korea.
  • Han SH; Department of Chemistry, Kangwon National University, Chuncheon 24341, Republic of Korea.
  • Han GU; Department of Chemistry, Kangwon National University, Chuncheon 24341, Republic of Korea.
  • Chan Noh H; Department of Chemistry, Kangwon National University, Chuncheon 24341, Republic of Korea.
  • Lee K; Department of Chemistry, Kangwon National University, Chuncheon 24341, Republic of Korea.
  • Kim D; Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.
  • Lee PH; Center for Catalytic Hydrocarbon Functionalizations, Institute for Basic Science (IBS), Daejeon 34141, Republic of Korea.
Org Lett ; 24(19): 3526-3531, 2022 May 20.
Article em En | MEDLINE | ID: mdl-35533400
ABSTRACT
Transition-metal-free synthetic method for o-carborane-fused pyrazoles as a new scaffold has been developed from the reaction of B(4)-acylmethyl or B(3,5)-diacylmethyl o-carborane with 2-azido-1,3-dimethylimidazolinium hexafluorophosphate (ADMP) in the presence of DBU in acetonitrile through sequential diazotization and cyclization reaction in one pot, consequently allowing twofold C-N bond formation under extremely mild conditions and high functional group tolerance.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article