Reliability analysis of exonic-breakpoint fusions identified by DNA sequencing for predicting the efficacy of targeted therapy in non-small cell lung cancer.

Li, Weihua; Wan, Rui; Guo, Lei; Chang, Geyun; Jiang, Dong; Meng, Lin; Ying, Jianming

Li, Weihua; Wan, Rui; Guo, Lei; Chang, Geyun; Jiang, Dong; Meng, Lin; Ying, Jianming.

Afiliação

Li W; Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.17 Panjiayuan Nanli, Beijing, 100021, China. liweihua@cicams.ac.cn.
Wan R; Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Guo L; Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.17 Panjiayuan Nanli, Beijing, 100021, China.
Chang G; Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Jiang D; Beijing Novogene Bioinformatics Technology Co., Ltd., Beijing, China.
Meng L; Beijing Novogene Bioinformatics Technology Co., Ltd., Beijing, China.
Ying J; Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.17 Panjiayuan Nanli, Beijing, 100021, China. jmying@cicams.ac.cn.

BMC Med ; 20(1): 160, 2022 05 10.

Article em En | MEDLINE | ID: mdl-35534835

Assuntos

Carcinoma Pulmonar de Células não Pequenas; Neoplasias Pulmonares; Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico; Carcinoma Pulmonar de Células não Pequenas/genética; Carcinoma Pulmonar de Células não Pequenas/patologia; DNA; Éxons/genética; Sequenciamento de Nucleotídeos em Larga Escala; Humanos; Hibridização in Situ Fluorescente; Neoplasias Pulmonares/tratamento farmacológico; Neoplasias Pulmonares/genética; Neoplasias Pulmonares/patologia; Proteínas de Fusão Oncogênica/genética; Proteínas de Fusão Oncogênica/metabolismo; Proteínas de Fusão Oncogênica/uso terapêutico; RNA; Reprodutibilidade dos Testes; Análise de Sequência de DNA

Palavras-chave

Alternative splicing; DNA sequencing; Exonic-breakpoint fusion; Non-small cell lung cancer; Targeted therapy

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Neoplasias Pulmonares Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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