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Magnetic Biohybrid Robots as Efficient Drug Carrier to Generate Plant Cell Clones.
Huska, Dalibor; Mayorga-Martinez, Carmen C; Zelinka, Radim; Pumera, Martin.
Afiliação
  • Huska D; Center for Advanced Functional Nanorobots, Department of Inorganic Chemistry, Faculty of Chemical Technology, University of Chemistry and Technology Prague, Technická 5, Prague, 166 28, Czech Republic.
  • Mayorga-Martinez CC; Department of Chemistry and Biochemistry, Mendel University in Brno, Zemedelska 1, Brno, 61300, Czech Republic.
  • Zelinka R; Center for Advanced Functional Nanorobots, Department of Inorganic Chemistry, Faculty of Chemical Technology, University of Chemistry and Technology Prague, Technická 5, Prague, 166 28, Czech Republic.
  • Pumera M; Department of Chemistry and Biochemistry, Mendel University in Brno, Zemedelska 1, Brno, 61300, Czech Republic.
Small ; 18(23): e2200208, 2022 06.
Article em En | MEDLINE | ID: mdl-35535470
Micro/nanorobots represent a new generation of micromachines that can accomplish various tasks, such as loading and transporting specific targets or pharmaceuticals for a given application. Biohybrid robots consisting of biological cells (bacteria, sperm, and microalgae) combined with inorganic particles to control or propel their movement are of particular interest. The skeleton of these biohybrid robots can be used to load biomolecules. In this work, the authors create biohybrid robots based on tomato plants by coculturing ferromagnetic nanoparticles (Fe3 O4 ) with tomato callus cells. The tomato-based biohybrid robots (Tomato-Biobots) containing Fe3 O4 nanoparticles  are driven by a transversely rotating magnetic field. In addition, biohybrid robots are used to load vitamin C, to generate clones of tomato cells. It is shown that the presence of Fe3 O4  does not affect the growth of tomato callus. This study opens a wide range of possibilities for the use of biohybrid robots@Fe3 O4  to deliver conventional agrochemicals, including fertilizers, pesticides, and herbicides, and allows for a gradual and sustained release of nutrients and agrochemicals, leading to precise dosing that reduces the amount of agrochemicals used. This conceptually new type of micromachine with application to plants and agronomy shall find broad use in this field.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Robótica / Portadores de Fármacos Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Robótica / Portadores de Fármacos Idioma: En Ano de publicação: 2022 Tipo de documento: Article